The Clarets looked to continuing their positive start to the season by claiming a 2-2 draw at Old Trafford, after fighting back not once, not twice to level.
But referee Sam Barrott overturned a late decision not to award United a penalty, with Bruno Fernandes stepping up and slotting home to win it for the home side at the death.
VAR had earlier got involved to deny Lyle Foster a second goal when he rounded the keeper to slot home, only to be ruled offside by the barest of margins.
United also had a first-half penalty overturned after Kyle Walker and Mason Mount had tussled right on the 18-yard box.
Here’s how Burnley’s players rated:
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5. Jacob Bruun Larsen - 6/10
Provided the cross that led to Burnley’s first equaliser through Foster, but otherwise spent most of the afternoon tracking back and defending. (Photo by OLI SCARFF/AFP via Getty Images) Photo: OLI SCARFF
6. Quilindschy Hartman - 6/10
Struggled to deal with Amad during the first-half, even though he did clearly win the ball for United’s second penalty appeal. Saw a shot well blocked from a partially cleared long throw. (Photo by OLI SCARFF/AFP via Getty Images) Photo: OLI SCARFF
7. Josh Cullen - 7/10
So unfortunate United’s first went down as his own goal, with the ball rebounding in off his shoulder. Covered plenty of ground. (Photo by Matt McNulty/Getty Images) Photo: Matt McNulty
8. Lesley Ugochukwu - 8/10
The one Burnley player during the first-half that looked to move forward and break lines. Offers such a big presence in the middle of the park. (Photo by OLI SCARFF/AFP via Getty Images) Photo: OLI SCARFF