The Clarets' opponents have won all of their last meetings, and Sean Dyche's side face a real uphill struggle to get anything out of the match.
When the two sides last faced each other, back in October, City secured a 2-0 win at the Etihad Stadium.
Speaking ahead of the game, Burnley goalkeeper Nick Pope, who played for England during the international break, said: “When you play teams around you it is always going to be important but first of all City is a massive game for us.
“It’s a home game and we can’t just sit back and write it off, that is not our style. We want to get out there and use it as an opportunity to start a good run for ourselves.
“They are the tough challenges of the Premier League, but they are the reason you want to play in the Premier League, against the top teams and top players. It's a challenge we're looking forward to, a home game, and we'll be looking to take it on and do what's right to get a positive outcome.”
Just a draw would be enough to see Dyche's men leapfrog Watford into 18th place, and Burnley's underdog status heading into the game will see them determined to pull off a shock result against the Premier League champions.
Take a look at the latest news and transfer stories from the Premier League, as the build-up to the weekend action continues:
1. Ronaldo heading for exit?
Manchester United forward Cristiano Ronaldo has been tipped to leave the club this summer. Portuguese side giants Porto are believed to be ready to make a move, ahead of the superstar’s participation in the 2022 World Cup this winter. (Football Insider)
2. New deal for Azpilicueta
Chelsea skipper Cesar Azpilicueta has extended his contract with the club by another year. The 32-year-old star has won every trophy possible with the Blues, racking up the mighty haul over a ten season period. (Sky Sports)
3. Foxes target available on the cheap
Leicester City transfer target Mohamed-Ali Cho has seen his asking price slashed from €40m to €20m, according to reports. However, they face competition from Borussia Dortmund and Real Betis to sign the Angers forward. (Foot Mercato)
4. Toffees eye Danish defender
Everton are said to be keen on Leicester City defender Jannick Vestergaard. The £15m ex-Southampton ace could move on this summer after struggling for game time at the King Power Stadium. (Football Insider)