When the two sides last met, back in mid-January, it was the Hammers who came out on top, with Michail Antonio's early finish proving decisive.
As things stand, the Clarets are 14th in the table, nine points clear of Fulham in 18th with just 15 points left to play for. The Clarets gave themselves a little bit of breathing space from the bottom three following a fantastic 4-0 win over Wolves at Molineux.
Striker Chris Wood was the man of the moment when netting a first half hat-trick, which saw him usurp Ashley Barnes as the club's all-time top Premier League goalscorer with 43.
The New Zealander, who has netted six times for the Clarets against West Ham in the top flight, has now hit double figures in four successive seasons at this level, a record only matched by Harry Kane, Mohamed Salah, Jamie Vardy, Heung-Min Son and Alexandre Lacazette.
Dyche said: "Striker is the hardest role on the pitch, I used to be a centre half and I made sure it was difficult for them, trust me!
"I've never really over-questioned centre forwards because of the respect I have for the position.
"Woody is still improving his hold up play and some of the simpler things - not simple, important but simple things - keeping the ball for the team...
"But he finds a way of scoring goals, and coaches and managers marvel at that."
Here are today's biggest transfer stories and the latest team news involving Burnley and the rest of the Premier League, as the reaction to the midweek action continues:
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Lionel Messi of FC Barcelona celebrates after scoring their side's first goal during the UEFA Champions League Round of 16 match between FC Barcelona and Paris Saint-Germain at Camp Nou on February 16, 2021 in Barcelona, Spain. Photo: David Ramos
. Martin Odegaard going nowhere
Real Madrid are not prepared to sell the 22-year-old Norwegian midfielder, who is on loan at Arsenal until the end of the season. (Marca) Photo: Dan Mullan
. Ex-Gunners boss backs takeover bid
Former Arsenal manager Arsene Wenger is believed to be ready to back a potential takeover bid, alongside Spotify chief Daniel Ek and three former players, Patrick Vieira, Thierry Henry and Dennis Bergkamp. (BeIN Sports, via Mirror)
However, Arsenal owners Stan Kroenke and Josh Kroenke "are not selling any stake" in the club. Photo: Valeriano Di Domenico
1. Martin Odegaard going nowhere
Real Madrid are not prepared to sell the 22-year-old Norwegian midfielder, who is on loan at Arsenal until the end of the season. (Marca) Photo: Dan Mullan
2. Ex-Gunners boss backs takeover bid
Former Arsenal manager Arsene Wenger is believed to be ready to back a potential takeover bid, alongside Spotify chief Daniel Ek and three former players, Patrick Vieira, Thierry Henry and Dennis Bergkamp. (BeIN Sports, via Mirror)
However, Arsenal owners Stan Kroenke and Josh Kroenke "are not selling any stake" in the club. Photo: Valeriano Di Domenico
3. Sancho to replace Salah?
Jurgen Klopp could attempt to sign Jadon Sancho from Borussia Dortmund if Mohamed Salah leaves Liverpool this summer. (Daily Mail) Photo: Ina Fassbender
4. Lingard looking to nail down a move to Hammers?
England forward Jesse Lingard, who could feature at Turf Moor on Monday, is willing to push for a permanent exit from Manchester United this summer, with West Ham keen on concluding a deal. (Daily Mirror) Photo: David Rogers