When the two sides last met, back in mid-January, it was the Hammers who came out on top, with Michail Antonio's early finish proving decisive.
As things stand, the Clarets are 14th in the table, nine points clear of Fulham in 18th with just 15 points left to play for. The Clarets gave themselves a little bit of breathing space from the bottom three following a fantastic 4-0 win over Wolves at Molineux.
Striker Chris Wood was the man of the moment when netting a first half hat-trick, which saw him usurp Ashley Barnes as the club's all-time top Premier League goalscorer with 43.
The New Zealander, who has netted six times for the Clarets against West Ham in the top flight, has now hit double figures in four successive seasons at this level, a record only matched by Harry Kane, Mohamed Salah, Jamie Vardy, Heung-Min Son and Alexandre Lacazette.
Dyche said: "Striker is the hardest role on the pitch, I used to be a centre half and I made sure it was difficult for them, trust me!
"I've never really over-questioned centre forwards because of the respect I have for the position.
"Woody is still improving his hold up play and some of the simpler things - not simple, important but simple things - keeping the ball for the team...
"But he finds a way of scoring goals, and coaches and managers marvel at that."
Here are today's biggest transfer stories and the latest team news involving Burnley and the rest of the Premier League, as the reaction to the midweek action continues:
13. Hammers ready to snap up Young Lion from rivals
West Ham are hopeful they will be able to sign Arsenal and England Under-21 striker Eddie Nketiah this summer. (Evening Standard) Photo: Justin Setterfield
14. Young set to re-sign for newly-promoted Hornets
Watford are set to offer former winger Ashley Young, 35, a one-year deal after sealing promotion back to the Premier League. The former England international's contract expires in the summer. (Daily Mail) Photo: Gabriele Maltinti
15. Messi making move to the Premier League?
Lionel Messi is out of contract at Barcelona, and available on a free transfer, with Manchester City again linked with the Argentina forward - although PSG are confident of landing the 33-year-old. Photo: Pau Barrena
16. Former Clarets ace on his way to City?
Champions elect Manchester City are favourites to land ex-Burnley forward Danny Ings. SkyBet have priced the Premier League leaders up at 5/2 to sign the Southampton striker, who has netted 10 times in the top flight this term. Photo: Adam Davy