While Maxime Esteve is back from injury and Axel Tuanzebe, Hannibal and Lyle Foster have now all returned from AFCON, the Clarets’ squad continues to be stretched.
Parker has often made wholesale changes in cup competitions – and with Burnley’s priority being Premier League survival, you’d expect the same to be the case this weekend.
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But the Clarets aren’t the only side with selection issues, with Millwall also likely to be without a number of key names.
Both sides have some injury concerns to contend with heading into Saturday’s encounter, so here's an early look at the team news for both outfits:
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13. Zak Lovelace (Millwall) - out
The forward recently suffered a recurrence of the hamstring injury that has limited him to just one appearance this season. (Photo by Carl Recine/Getty Images) Photo: Carl Recine
14. Massimo Luongo (Millwall) - out
He’s been ruled out for the remainder of the season after rupturing the anterior cruciate ligament in his right knee. (Photo by Richard Pelham/Getty Images) Photo: Richard Pelham
15. Will Smallbone (Millwall) - out
The experienced midfielder hasn’t played since October due to a hamstring injury. (Photo by Richard Pelham/Getty Images) Photo: Richard Pelham