While Maxime Esteve is back from injury and Axel Tuanzebe, Hannibal and Lyle Foster have now all returned from AFCON, the Clarets’ squad continues to be stretched.
Parker has often made wholesale changes in cup competitions – and with Burnley’s priority being Premier League survival, you’d expect the same to be the case this weekend.
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But the Clarets aren’t the only side with selection issues, with Millwall also likely to be without a number of key names.
Both sides have some injury concerns to contend with heading into Saturday’s encounter, so here's an early look at the team news for both outfits:
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9. Luke Cundle (Millwall) - doubt
Cundle is also closing in on a return having been sidelined with a shoulder issue since the end of November. (Photo by Harry Murphy/Getty Images) Photo: Harry Murphy
10. Casper De Norre (Millwall) - doubt
The midfielder suffered a calf injury in early December but it’s not thought to be a problem that will keep him out for too long. (Photo by Andrew Redington/Getty Images) Photo: Andrew Redington
11. Dan Kelly (Millwall) - out
The midfielder is thought to be a longer-term injury concern with a hamstring injury he suffered last month. (Photo by David Rogers/Getty Images) Photo: David Rogers
12. Lukas Jensen (Millwall) - out
The former Burnley goalkeeper is facing months on the sidelines with a quad injury, having just overcome a torn Achilles. (Photo by Paul Harding/Getty Images) Photo: Paul Harding