Even without a depleted squad, the Clarets boss would have rested the vast majority of his starting XI – as we’ve witnessed in cup competitions throughout his tenure.
But with eight players missing out against Manchester United in midweek and the squad still stretched, he’ll certainly use this occasion to hand minutes to fringe players and perhaps even the odd youngster or two.
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Parker is boosted by the return of the three AFCON players, Axel Tuanzebe, Hannibal and Lyle Foster, while Maxime Esteve also returned from injury in midweek.
But with Premier League survival clearly the priority, how many changes can we expect to see?
Here’s how we expect Burnley to line up:
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1. GK - Max Weiss
The summer signing will get another chance to show what he can do, as he did in the Carabao Cup earlier in the season (Photo by Ben Roberts Photo/Getty Images) Photo: Ben Roberts Photo
2. RB - Oliver Sonne
Given Kyle Walker's recent form, this could be a big opportunity for Sonne to stake a real claim (Photo by Steve Bardens/Getty Images) Photo: Steve Bardens
3. CB - Axel Tuanzebe
Assuming he's fit and available on his return from AFCON, Tuanzebe could start and give the likes of Esteve and Humphreys a rest (Photo by Molly Darlington/Getty Images) Photo: Molly Darlington
4. CB - Hjalmar Ekdal
Having been dropped for the midweek Man Utd game, Ekdal should be fresh to play (Photo by Glyn KIRK / AFP via Getty Images) Photo: GLYN KIRK