Vincent Kompany has revealed the winger is set for a lengthy period on the sidelines after suffering a serious knee injury during the midweek defeat to Burnley.
Elsewhere, Josh Cullen, Jack Cork and Lyle Foster remain sidelined, but on a more positive note Jordan Beyer is back from suspension.
With that in mind, here’s how we think the Clarets could line up at the Amex:
5. LB - Charlie Taylor
The experienced full-back will have to be on high alert, with Brighton possessing plenty of attacking talent. Photo: David Rogers
6. CM - Josh Brownhill
The skipper has performed well in recent weeks alongside Sander Berge in central midfield. Photo: Michael Regan
7. CM - Sander Berge
While the midfielder was arguably at fault for Wolves' goal on Tuesday night, he's still been one of Burnley's best performers in recent weeks. Photo: David Rogers
8. RW - Johann Gudmundsson
Jacob Bruun Larsen failed to take his chance in midweek, while Gudmundsson offers more defensive stability. Photo: David Rogers