Scott Parker’s men will be keen to cut the gap to the Blades, who currently lead the way by three points. Leeds United sit second, while the Clarets trail in third place a further point back.
Last time out Burnley claimed a deserved 2-1 win against Watford to extend their unbeaten run to nine games.
Parker made the unusual decision to name four central midfielders, with Hannibal playing out on the left wing. While it was a gamble that worked, will he look to replicate it in such a high-profile game?
Connor Roberts picked up a slight ankle issue late on against Watford but is expected to be fine, while Parker also hopes to have Jeremy Sarmiento back in contention.
With that in mind, here’s how we think the Clarets might line up at Bramall Lane:
5. LB - Bashir Humphreys
Given Burnley are likely to come under more pressure than usual, you'd expect the more defensive-minded Humphreys to be preferred to Lucas Pires again. Photo: Molly Darlington
6. CM - Josh Cullen
The midfielder was back to his best against Watford last week but will need to replicate that performance against Sheffield United's dangerous midfield. Photo: Gareth Copley
7. CM - Hannibal
The former Manchester United man was superb playing out on the wing against Watford, but we expect he might play more centrally for this one. Photo: Molly Darlington
8. CM - Josh Brownhill
The skipper is likely to play a little further ahead of the two central midfielders behind him once again. Can he add to his eight goals? Photo: Molly Darlington