Unbeaten in 17 games in league and cup, Scott Parker’s men will be desperate to build on Monday night’s 0-0 draw with leaders Leeds with a victory.
The Clarets currently sit third in the table, just a point off Sheffield United.
As for Pompey, they remain 21st and just two points above the dropzone following their midweek 1-0 defeat to Millwall.
Burnley are unlikely to have any of their injured players back for this one, but they will have one or two waiting in the wings pushing to start.
With that in mind, here’s how we think the Clarets might line up:
5. LB - Bashir Humphreys
While Scott Parker likes to rotate his left-backs, Lucas Pires is more likely to get the nod against Oxford on Tuesday night. Photo: Matt McNulty
6. CM - Josh Cullen
The midfielder was tightly marked during Monday night's stalemate against Leeds so his creativity was stifled, but defensively he put in another good shift. Photo: Matt McNulty
7. CM - Josh Laurent
Jonjo Shelvey will be pushing to be involved, but according to Scott Parker the new signing still needs more time on the training field. Photo: Matt McNulty
8. CAM - Josh Brownhill
A few things didn't quite come off for Brownhill against Leeds, but he's still absolutely instrumental to this Burnley side with nine goals to his name. Photo: Matt McNulty