St Mary's has been a happy hunting ground for the Clarets recently as Sean Dyche's side have clocked up seven points against Southampton from their last three visits in the top flight.
Matej Vydra was the hero of the hour last term when restoring Burnley s lead with a thumping finish past Alex McCarthy.
Former Claret Danny Ings had previously found the net in the 18th minute to cancel out Ashley Westwood's early opener direct from a corner kick.
The Saints, who share an identical points return and goal difference with Sunday's opponents on the South Coast, claimed the bragging rights earlier on in the season when Ings' first half finish proved to be the difference at Turf Moor.
Southampton v Burnley LIVE
Last updated: Sunday, 04 April, 2021, 13:55
Full-time: Southampton 3 Burnley 2
It ends in defeat for the Clarets
Saints go close to finishing the game off
Adams races clear, but the striker slides the ball the wrong side of the post.
Burnley make another change
Teenager Richardson is Gudmundsson’s replacement
Another change for the Saints
Djenepo replaces Walcott for Southampton
Ings is withdrawn and Adams is his replacement.
Big chance for Burnley
Wood is denied from point blank range. McNeil’s cross travels through and Wood heads straight at Forster.
Rodriguez is on for Vydra
Change for the hosts. Armstrong makes way for Salisu.
Big save from Forster
The Southampton goalkeeper gets across to claw the ball away after Wood attempts to bend the ball into the far corner.
GOAL: Southampton 3 Burnley 2
The home side have turned it around. Pope produces another fantastic save to keep out Ings, but Walcott lifts the ball back into the box and Redmond converts.