Burnley will be among the clubs looking to avoid the drop after securing their return to the top flight with a 100-point finish in the Championship.
With all six newly-promoted clubs facing instant relegation during the past two seasons, Scott Parker and his players will have to get used to being written off.
There’s no doubt the gap is growing, however, with 13 points separating Leicester City in 18th and Tottenham – the Europa League winners – one position above.
But given some well-documented off-the-field issues, Spurs aren’t the only big club to be in the picture for next season’s relegation odds.
Here’s the current forecast according to bet365:
1. Challenge
Burnley will be one of the big favourites for relegation following their promotion from the Championship (Photo by Alex Livesey/Getty Images) Photo: Alex Livesey
2. Tottenham - 40/1
Despite lifting the Europa League, Spurs finished this season in 17th place, so can't be ruled out! Photo: Justin Setterfield
3. Man City - 20/1
On the face of it this might seem absurd, but given a decision on those 115 charges is expected soon, it might not be as ludicrous as it first sounds. Photo: Alex Davidson
4. Man Utd - 16/1
The Red Devils are in chaos on and off pitch and missing out on Champions League football could land another significant blow. Photo: Matt McNulty