Scott Parker’s side have known for some time now they’re heading back to the Championship, but this could be the night it’s officially confirmed.
They face a City side that have plenty to play for, having beaten rivals Arsenal 2-1 at the weekend to throw the title race wide open.
The Burnley Express has launched a new WhatsApp channel to bring the latest news, analysis and team & injury updates directly to your phone. Simply click this link to join our Burnley Express WhatsApp channel.
Pep Guardiola’s side, who have an imperious record against the Clarets down the years, will go top of the table with three points at Turf Moor.
Both sides have some injury concerns to contend with heading into Wednesday night’s encounter, so here's an early look at the team news for both outfits:
Your next Burnley FC read: Spot a Burnley supporter you know in these 30 photos from Forest away end
5. Connor Roberts (Burnley) - out
The Welshman has returned to training from an Achilles injury that has kept him out for the entirety of the season, but is still some weeks away. (Photo by Alex Livesey/Getty Images) Photo: Alex Livesey
6. Ruben Dias (Man City) - doubt
The centre-back has missed the last two games with an ankle injury but there is a slim chance he could be back for this one. (Photo by Florencia Tan Jun/Getty Images) Photo: Florencia Tan Jun
7. Josko Gvardiol (Man City) - out
The defender suffered a broken leg in January and is unlikely to make a return before the season is up. (Photo by Oli SCARFF / AFP via Getty Images) Photo: OLI SCARFF
8. Rodri (Man City) - doubt
The midfielder was forced off against Arsenal on Sunday with a groin issue and will now undergo tests. (Photo by Darren Staples / AFP via Getty Images) Photo: DARREN STAPLES