Josh Cullen became the latest player to join the injury list on Saturday, hobbling off with what looked to be a knee injury during the 0-0 draw against Everton.
Joe Worrall was also absent from Burnley’s squad with a “niggle” he picked up in training.
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Maxime Esteve remains a fitness doubt, Jordan Beyer, Connor Roberts and Zeki Amdouni all remain sidelined, while Axel Tuanzebe, Hannibal and Lyle Foster are all away at AFCON.
With that in mind, here’s how we expect the Clarets to line up:
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5. CB - Bashir Humphreys
Humphreys was excellent on his first Premier League start on Saturday, but is he fit enough to play another 90 minutes? Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard
6. LWB - Lucas Pires
The Brazilian performed well again against Everton at the weekend and currently has the shirt ahead of Quilindschy Hartman. Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard
7. CM - Florentino Luis
With Josh Cullen surely guaranteed to miss out, Florentino is the natural replacement in the middle of the park. Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard
8. CM - Lesley Ugochukwu
The Frenchman offered a real physical presence against Everton, something he'll have to repeat against a strong Newcastle midfield. Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard