Scott Parker’s side are now without a win in their last 11 games, a run that stretches back to the end of October.
During those 11 games, nine games have ended in defeat – with the last one coming with a 2-0 reversal at the hands of Brighton on Saturday.
On Wednesday night they face a Manchester United side that sit sixth in the table off the back of a 1-1 draw with their rivals Leeds United on Sunday.
The Burnley Express has launched a new WhatsApp channel to bring the latest news, analysis and team & injury updates directly to your phone. Simply click this link to join our Burnley Express WhatsApp channel.
Burnley’s squad continues to look depleted, although they could be boosted by the return of a couple of players from AFCON and potentially one or two from injury.
With that in mind, here’s how we expect the Clarets to line up:
Your next Burnley FC read: Burnley boss Scott Parker explains why Marcus Edwards was dropped against Brighton
5. CB - Bashir Humphreys
He's highly unlikely to be 100% match fit at this moment in time, but Burnley have very few other options at centre back (Photo by Glyn KIRK / AFP via Getty Images) Photo: GLYN KIRK
6. LWB - Lucas Pires
With Quilindschy Hartman left out once again at Brighton, the left back/wing back role is Pires' to lose (Photo by Mike Hewitt/Getty Images) Photo: Mike Hewitt
7. CM - Florentino Luis
He was far from flawless at Brighton on Saturday, but he continued to press, harry and close down right until the last minute (Photo by Steve Bardens/Getty Images) Photo: Steve Bardens
8. CM - Lesley Ugochukwu
The Frenchman battled through sickness to play at Brighton on Saturday, but sadly you could tell he was off the pace (Photo by Steve Bardens/Getty Images) Photo: Steve Bardens