The Clarets boss opted to start with a back five against Brentford on Saturday but it was a decision that backfired, with the Bees racing into a 3-0 first-half lead.
Burnley soon reverted to a back four and it coincided with a comeback, as Parker’s side fought their way back to 3-3.
The hosts went all out for the three points they needed to keep their survival hopes alive, and even had two goals disallowed by VAR, before being stung right at the death.
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Heading to the Hill Dickinson Stadium for the first time on Tuesday night, will Parker stick with the back five or go with the more bold approach?
Both formations have had limited success this season, but with nothing to lose, Clarets fans will be keen to see their side try and take the game to David Moyes’ men.
With that in mind, here’s how we think the Clarets will line up:
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1. GK - Martin Dubravka
After conceding four at the weekend against Brentford, he'll be keen for a far quieter night at the office on Tuesday. Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard
2. RB - Bashir Humphreys
If Burnley revert to a back four, it's likely to be Humphreys at right-back unless Kyle Walker is recalled (Photo by Matt McNulty/Getty Images) Photo: Matt McNulty
3. CB - Joe Worrall
The experienced centre-back will have been given nightmares on Saturday night after enduring a tough afternoon against Brentford's Igor Thiago. Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard
4. CB - Maxime Esteve
The Frenchman wore the captain's armband against Brentford on Saturday in the absence of Kyle Walker and Josh Cullen. Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard