The interim boss changed from a back five to a four last week and it paid off, as the Clarets produced an encouraging display during their 2-2 draw with Aston Villa.
Burnley showed far more purpose and intent to attack, as they opted to go toe-to-toe with the Europa League finalists.
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But playing Villa at home and title-chasing Arsenal away are two different matters altogether, so will Jackson stick with the brave approach or revert to a more pragmatic, conservative system?
With that in mind, here’s how we expect the Clarets to line up:
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5. LB - Lucas Pires
The Brazilian will have his hands full with Bukayo Saka, so he'll have to be at the top of his game (Photo by Naomi Baker/Getty Images) Photo: Naomi Baker
6. CM - Floreninto Luis
Florentino's ability to break up play could be important, but he just needs to learn to keep it simple in possession (Photo by Jan Kruger/Getty Images) Photo: Jan Kruger
7. CM - Lesley Ugochukwu
The Frenchman had a big hand in both of Burnley's goals last week, but now he needs to back it up and be consistent (Photo by Molly Darlington/Getty Images) Photo: Molly Darlington
8. CM - Hannibal
The midfielder will be fine to start again after being brought off against Villa as a precaution, rather than having an injury (Photo by Naomi Baker/Getty Images) Photo: Naomi Baker