Scott Parker’s side have made a good start to the season, sitting third in the table after nine games and just one point adrift of the leaders.
The Clarets will be keen to get back to winning ways though after being held to a frustrating goalless draw at home to Preston North End prior to the break.
Since then, Lyle Foster has picked up an injury playing for South Africa while Jordan Beyer, Hjalmar Ekdal, Joe Worrall, Hannes Delcroix, Aaron Ramsey, Manuel Benson and Nathan Redmond all remain sidelined.
With that in mind, here’s how we think the Clarets might line up:
5. LB - Lucas Pires
After an adjustment period, the Brazilian looks to have settled in and has been more solid defensively in recent games. Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard
6. CM - Josh Cullen
Cullen's passing will need to be at his pinpoint best if Burnley are going to deal with Wednesday's physicality and energy. Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard
7. CM - Josh Brownhill
Remains Burnley's top goalscorer this season with four goals from his 10 games in all competitions. Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard
8. CM - Hannibal
There's no doubt Hannibal brings energy and intensity to Burnley's midfield, but playing a little further forward he needs to add more end product. Photo: Kelvin Lister-Stuttard Photo: Kelvin Lister-Stuttard