Steve Bruce was without a Premier League win in 44 games when his side had been trailing at the break so the omens weren't good for the visitors when Matej Vydra put the Clarets ahead.
However, inspired by substitute Allan Saint-Maximin, the Magpies staged a remarkable recovery, turning the game around in a five-minute spell early in the second half.
The Frenchman teed up Jacob Murphy for the equaliser before slotting past Bailey Peacock-Farrell to put Newcastle in front.
Sean Dyche' s side have now won just one game in 11 in all competitions at Turf Moor since the turn of the year.
Here are the RATINGS.
The Frenchman teed up Jacob Murphy for the equaliser before slotting past Bailey Peacock-Farrell to put Newcastle in front.
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Burnley's English manager Sean Dyche reacts during the English Premier League football match between Burnley and Newcastle United at Turf Moor in Burnley, north west England on April 11, 2021. Photo: Jon Super
. Bailey Peacock-Farrell 6.2
Made an outstanding save to deny Gayle from point blank range in the first half and read the game well to come off his line to clear the danger on occasions. Look assured, but couldn't do anything to prevent either Newcastle goal. Photo: Jon Super
. Matt Lowton 6.1
Tested Dubravka with a dipping volley from outside the box in the second half. Defended astutely throughout, blocking crosses when showing Almiron/Ritchie/Longstaff outside, and used the ball well. Photo: Jon Super
9. Ashley Westwood 6.2
Energetic in the middle of the park, moved the ball well and had a hand in Burnley's opening goal. Always posed a threat from set-pieces, which gave Dubravka nightmares, but lost his way slightly later in the game. Photo: Clive Brunskill
10. Matej Vydra 7.2
Scored in successive games for the first time since last February, holding back to finish Wood's pull back. Another vibrant display, posed a threat, readily looking to take on defenders, gets in behind and stretches play. Photo: Molly Darlington
11. Chris Wood 6.9
Did ever-so-well to beat his man to pull the ball back from the byline for Burnley's opener. Linked up well with Vydra, but lacked a bit of composure in front of goal. Had a hard time in the air up against Clark, Fernandez and Dummett. Photo: Daniel Leal Olivas