Axel Tuanzebe, Hannibal and Lyle Foster are now all unavailable for the next few weeks after jetting off to Morocco to represent their respective nations.
On a more positive note, both Lucas Pires and Kyle Walker come back into contention after serving one-game bans against Fulham at the weekend.
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Both sides have some injury concerns to contend with heading into Saturday’s encounter, so here's an early look at the team news for both outfits:
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9. Bashir Humphreys (Burnley) - out
Scott Parker confirmed the defender’s recent absence from Burnley’s match day squads is a result of an injury setback, rather than team selection. (Photo by Ben Roberts Photo/Getty Images) Photo: Ben Roberts Photo
10. Connor Roberts (Burnley) - out
The Welshman, who has yet to feature this season, is facing months on the sidelines after suffering a setback in his return from an Achilles injury. (Photo by Alex Livesey/Getty Images) Photo: Alex Livesey
11. Axel Tuanzebe (Fulham) - AFCON
Having made his return from injury against Fulham, Tuanzebe now jets off to Africa to represent DR Congo at AFCON. (Photo by Mike Hewitt/Getty Images) Photo: Mike Hewitt