The company says the decision is not affecting services.
The fault has been detected in the new state-of-the-art trains built by CAF at its factory in Zaragoza
Scores of electric and diesel trains were commissioned by Northern as part of its commitment to modernise and improve its service in the North.
A spokesperson for Northern said: “A fault has been identified on some of the new fleet of trains built by CAF and operated by Northern.
“The fault is affecting the yaw dampers (a system designed to reduce swaying motion in the carriage) and has resulted in 22 trains being removed from service while the issue is investigated.
“Northern is now working closely with CAF to determine the cause of the fault and to fix the issue. The remaining 78 trains in Northern’s CAF fleet have been fully checked and are operating as normal.
"The units still in passenger service will be regularly checked as part of the ongoing engineering process.”
The spokesperson added: “At present, the temporary removal of the 22 trains, is not causing any impact on Northern’s timetabled services.”