Elsewhere, Manchester United and Chelsea are predicted to clinch the final two Champions League places, while Tottenham are backed to finish above Arsenal for a fifth consecutive season, according to unikrn's supercomputer that has worked out the final league table.
At the bottom of the table, promoted West Brom are evens to make a swift return to the Championship with Aston Villa, who are 2/1 to go down.
Everton's predicted finish of 9th would be another disappointing campaign, while Newcastle and Crystal Palace are 9/4 and 5/2 to be relegated so may also have a season to forget.
The supercomputer system is based on factoring a range of the most informative betting markets in terms of influencing the final outcome of the season including title winner, 'without top six' and relegation odds.
A unikrn spokesperson said: "Liverpool's time as champions of England will be short-lived and Manchester City will snatch back their crown, if the predictions are correct. One thing that won't change this season will be Tottenham's continued dominance in the league over rivals Arsenal.
"Elsewhere, two of the three promoted sides are set to go straight back down while Crystal Palace and Newcastle could be in for a difficult season."