Elsewhere, Manchester United and Chelsea are predicted to clinch the final two Champions League places, while Tottenham are backed to finish above Arsenal for a fifth consecutive season, according to unikrn's supercomputer that has worked out the final league table.
At the bottom of the table, promoted West Brom are evens to make a swift return to the Championship with Aston Villa, who are 2/1 to go down.
Everton's predicted finish of 9th would be another disappointing campaign, while Newcastle and Crystal Palace are 9/4 and 5/2 to be relegated so may also have a season to forget.
The supercomputer system is based on factoring a range of the most informative betting markets in terms of influencing the final outcome of the season including title winner, 'without top six' and relegation odds.
A unikrn spokesperson said: "Liverpool's time as champions of England will be short-lived and Manchester City will snatch back their crown, if the predictions are correct. One thing that won't change this season will be Tottenham's continued dominance in the league over rivals Arsenal.
"Elsewhere, two of the three promoted sides are set to go straight back down while Crystal Palace and Newcastle could be in for a difficult season."
1. Manchester City
The beaten Champions League quarter-finalists have been priced up at evens to reclaim their crown from rivals Liverpool. Photo: Oli Scarff (Getty Images)
2. Liverpool
The Reds won their first Premier League title by a wide margin last term, but the champions have been priced as wide as 7/4 to repeat that success in 2020/21. Photo: Owen Humphreys (Getty Images)
3. Manchester United
After breaking back into the top four and reaching the semi-final of the Europa League, the Red Devils are as short as 1/10 for another top six finish in the top flight. Photo: Wolfgang Rattay (Getty Images)
4. Chelsea
The Blues, who secured a top four finish in the Premier League while reaching the last 16 of the Champions League, are priced at 1/8 to register another top six finish in the top flight in 2020/21. Photo: Matthias Hangst (Getty Images)