The former Watford defender has won 119 of those fixtures, drawing 88. Here's a collection of some of the key moments from the 48-year-old's time in charge at Turf Moor.
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Striker Martin Paterson scored the first goal of Sean Dyche's tenure, beating goalkeeper Carl Ikeme in the 18th minute at Turf Moor. Charlie Austin netted Burnley's second.
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On their way to promotion to the Premier League, goals from Jason Shackell and Danny Ings secured a famous win at Ewood Park. It was the first time Burnley had got the better of their rivals in nearly 35 years.
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Ashley Barnes and Michael Kightly scored the crucial goals to seal promotion to the top flight in what was boss Sean Dyche's first full season at the helm.
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Scott Arfield netted the Clarets' first goal in the Premier League under Sean Dyche, but the Blues hit back with goals from Diego Costa, Andre Schurrle and Branislav Ivanovic.
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The Clarets claimed their first point and first clean sheet of the Sean Dyche era in the Premier League against Manchester United, who fielded then record signing Angel Di Maria.
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Ashley Barnes's goal was the difference as Burnley beat the Tigers at Turf Moor to secure Sean Dyche's first win in the Premier League.
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Winger George Boyd scored the only goal of the game, beating Joe Hart from outside the penalty area, as the Clarets beat defending champions Manchester City at home.
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Joey Barton, Sam Vokes, Andre Gray, Matthew Lowton and George Boyd were all on the scoresheet at the Stadium:mk to register Sean Dyche's biggest win as Burnley manager.
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Andre Gray converted a 16th minute penalty to give the Clarets the bragging rights over their arch rivals and wrap up their first home win against Rovers since Boxing Day 1978.
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Michael Keane scored a stoppage time equaliser to swing the Championship title race back in Burnley's favour. Jordan Rhodes had opened the scoring in the 70th minute for the visitors.
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Midfielder Joey Barton's deflected free kick was the difference at Deepdale at the start of a weekend where the title was effectively signed, sealed and delivered for the Clarets.
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We kick off with West Riding County Cup action at Elland Road as Brian Caswell battles for the ball.
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Bob Hazell, who was on trial with the Whites after being released by Leicester City, in action.
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Andy Ritchie was on the scoresheet that day along with strike partner Keith Edwards who bagged a brace.
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Keith Edwards fires towards goal in front of 13,334 at Elland Road. The Whites took the three points thanks to goals from Ian Baird and John Sheridan.