There have been 14 Premier League meetings between Burnley and Manchester United since Owen Coyle steered the Clarets back to the top flight via the play-offs in 2009.
Blake's strike, a stunning first time finish, from Stephen Jordan's cleared cross, marked the club's first goal in the PL and shocked Sir Alex Ferguson's defending champions.
Brian Jensen also denied Michael Carrick from the spot as the visitors, armed with the likes of Ryan Giggs, Wayne Rooney, Michael Owen and Dimitar Berbatov, failed to find the net.
Burnley have come out on top just once since, when Chris Wood and Jay Rodriguez beat David De Gea to silence the Theatre of Dreams last year.
However, Sean Dyche's side have lost just one of their last five fixtures at the home of the Red Devils.
Here's a recap of everything else that has happened in-between.
Brian Jensen also denied Michael Carrick from the spot as the visitors, armed with the likes of Ryan Giggs, Wayne Rooney, Michael Owen and Dimitar Berbatov, failed to find the net.
5. Manchester United 0 Burnley 0
October 29th, 2016: Tom Heaton was the hero as the Clarets claimed another point at the Theatre of Dreams. Jose Mourinho's side, who had been reduced to 10 men following the sending off of Ander Herrera, managed 38 shots on goal, but failed to find a way past the ex-England international. Photo: Alex Livesey
6. Burnley 0 Manchester United 2
April 23rd, 2017: "It's not easy to win here and it's even harder to be in control," said Jose Mourinho, after United secured their first league win at Turf Moor in 41 years. First half goals from Anthony Martial and Wayne Rooney inflicted the damage. Photo: Jan Kruger
7. Manchester United 2 Burnley 2
December 26th, 2017: The game will be remembered for one thing, and one thing only. Steven Defour's exceptionally exquisite set-piece. That gave Burnley a 2-0 lead at the break following Ashley Barnes's fine finish. However, Jesse Lingard's double denied the visitors all three points. Photo: Lindsey Parnaby
8. Burnley 0 Manchester United 1
January 20th, 2018: This wasn't one for the purists as Manchester United ground out a 1-0 win at Turf Moor. Anthony Martial's finish in the 54th minute was the difference as Burnley's run without a win in the Premier League stretched to seven games. Photo: Alex Livesey