Scott Parker’s men will be determined to issue a reaction after being knocked out of the cup at the fifth round stage with a 3-0 defeat to Preston North End.
While they were in cup action, Sheffield United beat QPR to extend their lead to Burnley in third back to five points.
With 12 games remaining, the Clarets now have one sole focus as they go all out for automatic promotion.
Still unbeaten in their last 21 league games, and yet to concede in 12 straight outings, Burnley will need to continue that form with a much-needed three points in the Welsh capital.
Both sides have some injury concerns to contend with heading into Tuesday night’s encounter, so here's an early look at the team news for both outfits:
9. Aaron Ramsey (Burnley) - out
Making good progress in his recovery from a serious knee injury, which he suffered back in February of last year. But not quite ready just yet. Photo: Matt McNulty
10. Mike Tresor (Burnley) - out
Despite making a recent return during the FA Cup tie against Reading, Tresor is not fit to play and is unlikely to be available for the foreseeable future. Photo: Lewis Storey