Officers were called at around 12-40pm to a report that a HGV travelling towards Blackburn Road on Higher Shuttleworth had careered off the carriageway.
The driver, a man in his 50s, was pronounced dead at the scene.
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Enquiries are ongoing to determine the cause of the collision.
Police are asking anyone who may have witnessed the collision to call 101, quoting log 618 of May 6.