The Centenary Way station will remain open 10am to 3pm from Saturday to Wednesday every week; it will be closed on Thursday and Friday.
A Burnley Council spokesman said: "The Burnley testing station is in high demand from local residents.
"It has dealt with, on average, 300 tests a day since it opened on August 10th (the highest number of any community testing facility in Lancashire).
"But as reported in the media, the national testing system is stretched.
"We are grateful to the county council and the Lancashire Resilience Forum that, while the hours of operation are reducing, the station will remain open for the foreseeable future."